Hyponatremia is the most common electrolyte disorder in lung cancer patients. In an analysis of nine consecutive clinical trials conducted jointly at four hospitals in Denmark and Sweden a serum sodium level.
Hyponatremia In Cancer Patients Time For A New Approach Sciencedirect
Hyponatremia detected in in-hospital cancer patients is associated with a longer hospital length of stay and an increased.
Hyponatremia and lung cancer. Hyponatremia incidence in malignancy may be underestimated. Hyponatremia seems to be an independent predictor of inferior survival in lung cancer patients especially in patients with NSCLC. The hyponatremia observed in patients with cancer usually results from nonosmotic release of vasopressin with consequent hypo-osmolar hyponatremia.
Lung cancer is the leading cause of cancer-related death globally. Who analyzed a population of patients with lymphoma breast cancer colorectal cancer small cell and non-small cell lung cancer. Similar results were obtained by Castillo et al.
Nausea pain and baroreceptor release of vasopressin also known as antidiuretic hormone ADH are common causes of excess ADH release while ectopic production of ADH from tumors such as small cell lung cancer is relatively rare. This condition may be related to many causes including incidental medications concurrent diseases and side effects of antineoplastic treatments or the disease itself. Hyponatremia was marginally associated with shorter PFS HR 13 P 07 across cancer types.
Short-term hyponatremia correction was associated with better survival. This condition may be related to many causes including incidental medications concurrent diseases and side effects of antineoplastic treatments or the disease itself. The impact of hyponatremia on the cost of care for cancer patients is significant.
Electrolyte imbalance has been associated with poor survival in lung cancer patients 2 - 4. Hyponatremia was negatively associated with OS in all types of tumor but the highest HRs were found in lymphoma HR 45 P 001 and in breast cancer HR 37 P 01. Small cell lung cancer SCLC occurs in 1520 of lung cancer.
Hyponatremia and hypercalcemia are most commonly associated with lung cancer among other cancer types 5 - 7. Hyponatremia defined as a plasma sodium concentration PNa. Hyponatremia in Lung Cancer Hyponatremia ielow blood sodium levels is the most common electrolyte imbalance disorder found in lung cancer patients.
Hyponatremia is a common electrolyte disorder in lung cancer patients especially in patients with small-cell lung cancer SCLC. Being usually asymptomatic hyponatremia may cause symptoms like nausea fatigue disorientation headache muscle cramps or even seizures particularly if severe and rapid decrease of serum sodium levels occurs. However data have been conflicting.
The length of hospital stay nearly doubles in patients with hyponatremia compared to those for cancer patients who are normonatremic and this difference may perhaps be attributed to the slow or unpredictable response to correction in patients with cancer. This condition can be related to a plethora. Hyponatremia may also impact response to cancer therapy.
Hyponatremia can be a potential negative prognostic factor in patients diagnosed with solid tumors or hematological malignancies such as lung cancer breast cancer lymphoma and colorectal cancer. Hyponatremia is reported approximately 15 of SCLC. Highly malignant small cell lung cancer SCLC tumors are often associated with paracrine and paraneoplastic syndromes.
Physicians caring for patients with breast cancer without lung or brain involvement diagnosed with SIADH without an obvious etiology should consider obtaining lung and brain imaging to rule out undiagnosed metastatic spread. Hyponatremia is the most common electrolyte disorder in lung cancer patients. The aim of this retrospective study is to investigate the association between hyponatremia and prognosis of SCLC.
In cirrhosis hyponatremia is associated with a higher morbidity and mortality. In a study of nonsmall cell lung cancer patients treated with platinum-based regimens there was a differential response to. Ten to 15 of patients with SCLC develop hyponatremia plasma sodium 125 mmolL a problem that has befuddled clinicians since its recognition in 1957.
Hyponatremia in lung cancer is most commonly related to the syndrome of inappropriate anti-diuretic hormone secretion SIADH 4 8 - 11. SIADH is associated with most malignancy types. Decompensated cirrhosis in liver cancer patients represents an additional complicating factor.
It has been proposed as a prognostic indicator of higher mortality. However the prevalence is much more pronounced in cancer patients affecting nearly half of patients. Hyponatremia is a frequent electrolyte abnormality in patients with small cell lung cancer SCLC.
Among cancer patients hyponatremia occurs most frequently with small cell lung cancer SCLC. The incidence of hyponatremia is higher than previously reported in lung cancer is high in lymphoma BC and CRC and is a negative prognostic indicator for survival. The incidence of pretreatment hyponatremia is high in patients with SCLC as well as with NSCLC.
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